Integrated bioanalytics represent a variety of important methods to acquire reliable information about the state of a biological system, e.g. by analysing tissues, body fluids (blood, plasma, urine, sweat…).
Common used methods include gas chromatography, HPLC, capillary electrophoresis etc. Bioanalytics thus pose an important tool to follow the physiological course of a new compound during drug development and define the PK/PD profile of the drug candidate.
This course deals with the application of bioanalytical methodology, while emphasis is given to sample preparation, small molecule strategies and biopharmaceuticals.
As compounds differ in their physic-chemical properties, appropriate analysis strategies are required for sample separation, pre-treatment, detection methodology and validation.
Students will acquire the necessary knowledge to understand the most common methods applied and will be able to define the basic needs to develop, prepare and perform integrated biomolecular analyses, as well as to review and evaluate studies in the bioanalytic field.
Case studies will support the learning outcome and GLP and authoritative guideline will be discussed.
The course consists of one week face-to-face training by academic and industry experts from the field, given on-site and concluded by an exam. This week is followed by an optional second week of self-study and/or e-learning.
A syllabus containing an introductory chapter, lecture hand-outs, list of abbreviations, definitions and reading material will be provided by the course leader 14 days prior to the course. The material for the home assignment will be provided during the first week of the course.
Prof.Dr. Wilfried Niessen, Faculty of Sciences, VU University Amsterdam, Amsterdam, The Netherlands
Dr. Christian Herling, Novo Nordisk, Copenhagen, Denmark
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