Clinical Quandaries in Anticoagulation Reversal

Overview

What you will study

There are multiple controversial topics in anticoagulation reversal without clear data supporting the best approach. These topics include fixed dose vs package insert dosing of prothrombin complex concentrates (PCC) for warfarin reversal, the choice of reversal (andexanet alfa) or replacement product (PCC) for oral Xa inhibitor reversal especially in the setting of urgent/emergent surgery and the role of laboratory monitoring and differentiation of clinical characteristics (bleed size and location) to drive institution prescribing guidelines and reversal order sets.

The Clinical Quandaries in Anticoagulation Reversal course offered by Harvard University style will include a dialogue with a hematologist and pharmacist at a large academic medical center in Boston, MA and will bring into the conversation typical cases and discussions with front line providers that will make this topic very relatable to other providers who manage these complicated patient cases.