Development of an Integrated Pipeline for Correlating and Predicting Orofacial Features and 2-photon Neural Data in Mice King Abdullah University of Science and Technology (KAUST)

Overview

Sensory perception is shaped by an animal’s internal state. A large portion of neural activity in the cortex is spontaneously active even in the absence of external stimuli. This spontaneous activity is modulated by the animal’s behavior and internal state.

Key Facts

This Development of an Integrated Pipeline for Correlating and Predicting Orofacial Features and 2-photon Neural Data in Mice (Internship) project from King Abdullah University of Science and Technology (KAUST) will involve using the face map module (Pachitariu, M. & Stringer, C. (2024)) to build a pipeline that will pre-process, annotate, extract keypoints from facial camera recording of mice undergoing in-vivo calcium recording. 

Compute and derived metrics such as principal components of the recorded orofacial movements and, using face map, apply Hidden Markov models to identify the activity sequences of the spontaneous behaviors and also output them into time series data and then correlate and predict neural activity.

Recommended Student Background

• Neuroscience

• Computational Neuroscience

• Physiology