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Overview
Although CLN6 is an endoplasmic reticulum (ER) transmembrane protein, its deficiency leads to lysosomal storage disease, underscoring a critical ER-lysosome functional connection. The Defining the Role of CLN6 in Lysosomal Function and Neurodegeneration (Internship) project from King Abdullah University of Science and Technology (KAUST) will focus on elucidating the downstream effects of CLN6 loss on both ER and lysosomal functions. Utilizing our existing CLN6 knockout mouse model, the student will further explore disease mechanisms in vivo.
Additionally, the student will acquire skills in immunoprecipitation of organelles, such as the ER and lysosomes, followed by downstream multi-omics analyses to investigate molecular alterations resulting from CLN6 deficiency.
Recommended Student Background
- Molecular Biology
- Cell Biology
- Biochemistry
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Visit programme websiteProgramme Structure
Desired Deliverables:
- Generation of CLN6 Knockout Cell Models: o Develop and validate CLN6 knockout cell lines to serve as in vitro models for studying neuronal ceroid lipofuscinosis type 6 (CLN6 disease).
- Derivation of Patient-Specific iPSCs: o Establish induced pluripotent stem cells (iPSCs) from fibroblasts of patients with homozygous CLN6 mutations, ensuring their pluripotency and genomic integrity.
- Comprehensive In vitro and In vivo Multi-Omics Analysis: o Conduct integrated multi-omics analyses—including proteomics and transcriptomics—on CLN6-deficient cell models, differentiated neurons, and brain tissues from CLN6 knockout mouse models to identify molecular alterations and affected pathways.
- Investigation of Pathogenic CLN6 Mutations: o Examine the impact of various pathogenic CLN6 mutations on protein function and subcellular localization, providing insights into genotype-phenotype correlations.
Check out the full curriculum
Visit programme websiteKey information
Duration
- Part-time
- 6 months
Start dates & application deadlines
You can apply for and start this programme anytime.
More details
- Application deadline: all year around
Language
English
PTE Academic 62
IELTS 6.5
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- 4.9/5 student rating
Delivered
On Campus
Campus Location
- Thuwal, Saudi Arabia
Disciplines
Biology Biochemistry Genetics View 5 other Short Courses in Biochemistry in Saudi ArabiaExplore more key information
Visit programme websiteWhat students do after studying
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Academic requirements
GPA 3.5
English requirements
PTE Academic 62
IELTS 6.5
Prepare for Your English Test
Cathoven AI IELTS Preparation AI-powered IELTS feedback. Clear, actionable, and tailored to boost your writing & speaking score. No credit card or upfront payment required.
- Trusted by 300k learners
- 98 accuracy using real exam data
- 4.9/5 student rating
Other requirements
General requirements
- Undergraduate students in 3rd year or above and master’s students.
- Minimum GPA: 3.5/4
- Curriculum Vitae (CV)
- Statement of purpose
- Contact details of 3 referees
- Official English language test score
Student Insurance via Studyportals Partner
Make sure to cover your health, travel, and stay while studying abroad. Even global coverages can miss important items like Additional medical costs, Repatriation, Liability etc. Make sure your student insurance covers your needs.
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Remember, countries and universities may have specific insurance requirements. To learn more about how student insurance work at King Abdullah University of Science and Technology (KAUST) and/or in Saudi Arabia, please visit Student Insurance Portal.
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Visit programme websiteTuition Fees
Tuition fees are shown in and the most likely applicable fee is shown based on your nationality.
-
International Applies to you
Applies to youNon-residentsFree -
Domestic Applies to you
Applies to youCitizens or residentsFree
Additional Details
- This is a fully-funded internship; it includes tuition, airfare, housing, medical insurance, visa reimbursement and a monthly stipend of $1,000.
Living costs
Thuwal
Saudi Arabia
2270 - 3445 SAR / month
The living costs include the total expenses per month, covering accommodation, public transportation, utilities (electricity, internet), books and groceries.
Funding
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